Combination of multicomponent KA² and Pauson–Khand reactions: short synthesis of spirocyclic pyrrolocyclopentenones

• Riccardo Innocenti,
• Elena Lenci,
• Gloria Menchi and
• Andrea Trabocchi

Beilstein J. Org. Chem. 2020, 16, 200–211, doi:10.3762/bjoc.16.23

• -accessible chemical space. Experimental General procedure (A) for the KA2 coupling reaction. CuI (0.2 equiv) was added in a dry sealed vial for microwave synthesis under a nitrogen flow. Then, ketone (1 equiv), alkyne (1.2 equiv) and amine (1.2 equiv) were successively added under a nitrogen flow, and the

Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors

• Christoph W. Grathwol,
• Nathalie Wössner,
• Sören Swyter,
• Adam C. Smith,
• Enrico Tapavicza,
• Robert K. Hofstetter,
• Anja Bodtke,
• Manfred Jung and
• Andreas Link

Beilstein J. Org. Chem. 2019, 15, 2170–2183, doi:10.3762/bjoc.15.214

• = quartet, m = multiplet and combinations thereof, br = broad. Infrared (IR) spectra were recorded on a Bruker Alpha FT-IR spectrometer equipped with a diamond ATR unit and are indicated in terms of absorbance frequency [cm−1]. Microwave synthesis was conducted in a Monowave 300 microwave synthesis reactor

An overview on recent advances in the synthesis of sulfonated organic materials, sulfonated silica materials, and sulfonated carbon materials and their catalytic applications in chemical processes

• Hashem Sharghi,
• Pezhman Shiri and
• Mahdi Aberi

Beilstein J. Org. Chem. 2018, 14, 2745–2770, doi:10.3762/bjoc.14.253

• -methyl-1H-imidazolium chloride (66) ILs were used as excellent catalysts and the reaction medium for microwave synthesis of quinoline derivatives 65 from substituted anilines 15 and glycerol (64, Scheme 11). Some advantages of these catalytic systems include: elimination of oxidizing agents, ease of

Mechanochemical synthesis of small organic molecules

• Tapas Kumar Achar,
• Anima Bose and
• Prasenjit Mal

Beilstein J. Org. Chem. 2017, 13, 1907–1931, doi:10.3762/bjoc.13.186

• reaction medium, solvent-free synthesis, microwave synthesis, use of different Lewis acids FeCl3, NiCl2, BiCl3, InBr3, use of Brønsted acids PTSA, etc. are also reported [129][130]. Recently, Mal and co-workers reported a mechanochemical Biginelli reaction by a subcomponent synthesis approach [131][132

Mechanochemical synthesis of thioureas, ureas and guanidines

• Vjekoslav Štrukil

Beilstein J. Org. Chem. 2017, 13, 1828–1849, doi:10.3762/bjoc.13.178

• -methoxyphenyl isothiocyanate, which required 45 minutes of manual grinding and 15 or 45 minutes of milling, due to its diminished electrophilicity. In the context of these results, it is reasonable to assume that the solvent-free microwave synthesis of diarylthioureas described by Li et al. actually proceeded

Fluorescent carbon dots from mono- and polysaccharides: synthesis, properties and applications

• Stephen Hill and
• M. Carmen Galan

Beilstein J. Org. Chem. 2017, 13, 675–693, doi:10.3762/bjoc.13.67

• overlap with the cell autofluorescence. Recent years have seen an increase in synthetic reports of large scale N-doped CDs with good QYs from carbohydrate starting materials. For example in 2014, Leitão et al. described the microwave synthesis of CDs using 2.5 g of glucose and 0.3 g of tryptophan as the N

Efficient access to β-vinylporphyrin derivatives via palladium cross coupling of β-bromoporphyrins with N-tosylhydrazones

• Vinicius R. Campos,
• Ana T. P. C. Gomes,
• Anna C. Cunha,
• Maria da Graça P. M. S. Neves,
• Vitor F. Ferreira and
• José A. S. Cavaleiro

Beilstein J. Org. Chem. 2017, 13, 195–202, doi:10.3762/bjoc.13.22

• ) using CHCl3 as solvent. For the reactions under MW irradiation a CEM Microwave Synthesis System Discover SP was used, under constant magnetic stirring (controlled by the microwave equipment) by employing an irradiation power of 200 W till the reaction temperature (120 °C) was achieved. The UV–vis

A cross-metathesis approach to novel pantothenamide derivatives

• Jinming Guan,
• Matthew Hachey,
• Lekha Puri,
• Vanessa Howieson,
• Kevin J. Saliba and
• Karine Auclair

Beilstein J. Org. Chem. 2016, 12, 963–968, doi:10.3762/bjoc.12.95

• from 1 µM (triangles) to 100 μM (circles). From (R)-malic acid to allyl derivatives 8 and 9 tested in cross-metathesis. Details are provided in the main text. μ-wave: microwave. Synthesis of compounds 10c and 10d. Synthesis of 16. Optimization of the cross-metathesis reaction between 9 and various

One-step synthesis of pyridines and dihydropyridines in a continuous flow microwave reactor

• Mark C. Bagley,
• Vincenzo Fusillo,
• Robert L. Jenkins,
• M. Caterina Lubinu and
• Christopher Mason

Beilstein J. Org. Chem. 2013, 9, 1957–1968, doi:10.3762/bjoc.9.232

• dihydropyridine synthesis; heterocycles; microwave synthesis; multicomponent reactions; pyridine synthesis; Introduction Microwave-assisted synthesis has revolutionized many processes in recent years as a valuable alternative to the use of conductive heating for accelerating transformations in synthetic organic

Synthesis and crystal structures of multifunctional tosylates as basis for star-shaped poly(2-ethyl-2-oxazoline)s

• Richard Hoogenboom,
• Martin W. M. Fijten,
• Guido Kickelbick and
• Ulrich S. Schubert

Beilstein J. Org. Chem. 2010, 6, 773–783, doi:10.3762/bjoc.6.96

• chromatography. Microwave synthesis of 5,10,15,20-tetrakis(pEtOx)-21H,23H-porphyrin (star-PEtOx) A mixture of porphyrin tosylate 3 (7.92 mg, 0.005 mmol) and EtOx (100 mg, 1 mmol) in CH3CN (0.4 mL) was heated to 140 °C for 20 min under microwave irradiation. After heating, the solvent and residual monomer were